![]() ![]() In a recent prospective study of 288 depressed inpatients, severity of depression was equivalent in the 45% of patients with psychotic and the 55% with nonpsychotic depression, although functional impairment was greater in the psychotic patients. When psychosis was defined only as the presence of hallucinations or delusions, severity of depression was similar in the psychotic and nonpsychotic groups, and severity of depression was only weakly correlated with severity of psychosis. In a study of 357 inpatients (mean age 56–58 years, mean length of stay 44–50 days) with ICD-10 severe depression, one-third of whom had psychotic features, higher scores in psychotically depressed patients on the 12-item Health of the Nation Outcome Scales (HoNOS) severity rating scale were entirely attributable to the hallucinations/delusions subscale. Īccumulating research supports the impression that psychosis is not inextricably linked to severity of depression. This change reflects an understanding that many depressive disorders can occur with or without psychosis, with different implications for treatment and prognosis. ![]() In fact, DSM-5 permits psychotic features with dysthymia as well as major depression, acknowledging the idea that psychotic features are not just a function of severity of depression. In DSM-5, psychotic depression is still a subtype of MDD rather than a separate disorder, but the psychosis specifier is independent of severity, so that depression does not have to be severe to justify a diagnosis of psychotic depression. In DSM-IV, psychotic depression became a severe subtype of MDD characterized by delusions or hallucinations. An implication of this concept is that a more severe version of MDD may simply require more of the same treatment as other presentations, rather than a different therapeutic approach required by a distinct illness. All of these classifications considered psychotic depression to be a severe subtype of major depressive disorder (MDD). In other diagnostic systems, the concept of psychotic depression has variously included a level of severity that leads to distortion of reality, melancholic depression, endogenous depression, or the opposite of neurotic depression (defined in this context as depression with a psychosocial etiology). However, the subsequent version (ICD-11) includes hallucinations and delusions along with severity as diagnostic criteria. In ICD-10, the version that will continue until 2022, psychotic depression is still classified as a type of severe major depression. ![]() Although DSM-III eliminated severe impairment as the primary criterion for psychosis, this criterion remained in the International Classification of Diseases (ICD), especially if endogenous features were present. In this formulation, psychotic depression is at one end of a spectrum of severity and not a distinct disorder.Īfter reports that major depression with delusions had a different treatment response than major depression without delusions, the definition of psychotic depression was modified in DSM-III to require delusions, hallucinations, or depressive stupor. TEENAGE HALLUCINATION SYNDROME MANUALAs psychosis was defined in the second edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-II) as being so impaired mentally that the patient could not adapt to “the ordinary demands of daily life”, psychotic depression was defined solely by severe impairment, with or without the presence of delusions and hallucinations, which are traditional defining features of psychosis. The definition of psychotic depression has evolved so much over the years that it is difficult to apply experience with earlier diagnostic criteria to more recent experience. Evolution of the Concept of Psychotic Depression Typical features that have been studied formally are outlined, and case examples are used to illustrate more subtle or complex presentations and treatment approaches. This review addresses the complex ways in which psychosis can complicate mood disorders and the ways in which it alters their course and treatment response. In fact, psychotic depression remains a common condition that is often underrecognized and inadequately treated. Some clinicians believe that because modern rapid treatment of depression prevents it from becoming more severe, the development of psychotic features is now rare. ![]()
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